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Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A
Ubiquitination of misfolded proteins, a common feature of many neurodegenerative diseases, is mediated by different lysine (K) residues in ubiquitin and alters the levels of toxic proteins. In Huntington disease, polyglutamine expansion causes N-terminal huntingtin (Htt) to misfold, inducing neurode...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3992696/ https://ncbi.nlm.nih.gov/pubmed/24706802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402215111 |
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