Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype

Polycystic ovary syndrome (PCOS), characterized by increased ovarian androgen biosynthesis, anovulation, and infertility, affects 5–7% of reproductive-age women. Genome-wide association studies identified PCOS candidate loci that were replicated in subsequent reports, including DENND1A, which encode...

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Autori principali: McAllister, Jan M., Modi, Bhavi, Miller, Bruce A., Biegler, Jessica, Bruggeman, Richard, Legro, Richard S., Strauss, Jerome F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992676/
https://ncbi.nlm.nih.gov/pubmed/24706793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400574111
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