TCR-ligand k(off)-rate predicts protective capacity of antigen-specific CD8(+) T cells for adoptive transfer

Adoptive immunotherapy is a promising therapeutic approach for the treatment of chronic infections and cancer. Thereby, T cells within a certain range of high avidity for their cognate ligand are believed to be most effective. T cell receptor (TCR) transfer experiments indicate that a major part of...

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Autori principali: Nauerth, Magdalena, Weiβbrich, Bianca, Knall, Robert, Franz, Tobias, Dössinger, Georg, Bet, Jeannette, Paszkiewicz, Paulina J., Pfeifer, Lukas, Bunse, Mario, Uckert, Wolfgang, Holtappels, Rafaela, Gillert-Marien, Dorothea, Neuenhahn, Michael, Krackhardt, Angela, Reddehase, Matthias J., Riddell, Stanley R., Busch, Dirk H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3991308/
https://ncbi.nlm.nih.gov/pubmed/23825303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3005958
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