MHC Multimer-Guided and Cell Culture-Independent Isolation of Functional T Cell Receptors from Single Cells Facilitates TCR Identification for Immunotherapy

Adoptive therapy using T cells redirected to target tumor- or infection-associated antigens is a promising strategy that has curative potential and broad applicability. In order to accelerate the screening process for suitable antigen-specific T cell receptors (TCRs), we developed a new approach cir...

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Detalhes bibliográficos
Main Authors: Dössinger, Georg, Bunse, Mario, Bet, Jeannette, Albrecht, Julia, Paszkiewicz, Paulina J., Weißbrich, Bianca, Schiedewitz, Isabell, Henkel, Lynette, Schiemann, Matthias, Neuenhahn, Michael, Uckert, Wolfgang, Busch, Dirk H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637308/
https://ncbi.nlm.nih.gov/pubmed/23637823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061384
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