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Block of Human Cardiac Sodium Channels by Lacosamide: Evidence for Slow Drug Binding along the Activation Pathway

Lacosamide is an anticonvulsant hypothesized to enhance slow inactivation of neuronal Na(+) channels for its therapeutic action. Cardiac Na(+) channels display less and incomplete slow inactivation, but their sensitivity toward lacosamide remains unknown. We therefore investigated the action of laco...

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Bibliografiske detaljer
Main Authors: Wang, Ging Kuo, Wang, Sho-Ya
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3990017/
https://ncbi.nlm.nih.gov/pubmed/24563546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.091173
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