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Tryptophan Substitution of a Putative D4S6 Gating Hinge Alters Slow Inactivation in Cardiac Sodium Channels
Voltage-gated Na(+) channels display rapid activation gating (opening) as well as fast and slow inactivation gating (closing) during depolarization. We substituted residue S1759 (serine), a putative D4S6 gating hinge of human cardiac hNav1.5 Na(+) channels with A (alanine), D (aspartate), K (lysine)...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1305630/ https://ncbi.nlm.nih.gov/pubmed/15805167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.059352 |
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