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Negatively Charged Residues in the N-terminal of the AID Helix Confer Slow Voltage Dependent Inactivation Gating to Ca(V)1.2
The E462R mutation in the fifth position of the AID (α1 subunit interaction domain) region in the I-II linker is known to significantly accelerate voltage-dependent inactivation (VDI) kinetics of the L-type Ca(V)1.2 channel, suggesting that the AID region could participate in a hinged-lid type inact...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Biophysical Society
2004
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1304788/ https://ncbi.nlm.nih.gov/pubmed/15339810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.045559 |
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