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Sodium Channels: Ionic Model of Slow Inactivation and State-Dependent Drug Binding

Inactivation is a fundamental property of voltage-gated ion channels. Fast inactivation of Na(+) channels involves channel block by the III–IV cytoplasmic interdomain linker. The mechanisms of nonfast types of inactivation (intermediate, slow, and ultraslow) are unclear, although the ionic environme...

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Bibliografiske detaljer
Main Authors: Tikhonov, Denis B., Zhorov, Boris S.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1948041/
https://ncbi.nlm.nih.gov/pubmed/17496040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.100248
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