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Sodium Channels: Ionic Model of Slow Inactivation and State-Dependent Drug Binding
Inactivation is a fundamental property of voltage-gated ion channels. Fast inactivation of Na(+) channels involves channel block by the III–IV cytoplasmic interdomain linker. The mechanisms of nonfast types of inactivation (intermediate, slow, and ultraslow) are unclear, although the ionic environme...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Biophysical Society
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948041/ https://ncbi.nlm.nih.gov/pubmed/17496040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.106.100248 |
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