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State-dependent Block of Wild-type and Inactivation-deficient Na(+) Channels by Flecainide
The antiarrhythmic agent flecainide appears beneficial for painful congenital myotonia and LQT-3/ΔKPQ syndrome. Both diseases manifest small but persistent late Na(+) currents in skeletal or cardiac myocytes. Flecainide may therefore block late Na(+) currents for its efficacy. To investigate this po...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234482/ https://ncbi.nlm.nih.gov/pubmed/12913091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308857 |
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