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Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na(+) channels

Mexiletine is a class 1b antiarrhythmic drug used for ventricular arrhythmias but is also found to be effective for paramyotonia congenita, potassium-aggravated myotonia, long QT–3 syndrome, and neuropathic pain. This drug elicits tonic block of Na(+) channels when cells are stimulated infrequently...

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Bibliografiske detaljer
Main Authors: Wang, Ging Kuo, Russell, Corinna, Wang, Sho-Ya
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1664796/
https://ncbi.nlm.nih.gov/pubmed/14608007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.054973
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