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Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na(+) channels
Mexiletine is a class 1b antiarrhythmic drug used for ventricular arrhythmias but is also found to be effective for paramyotonia congenita, potassium-aggravated myotonia, long QT–3 syndrome, and neuropathic pain. This drug elicits tonic block of Na(+) channels when cells are stimulated infrequently...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1664796/ https://ncbi.nlm.nih.gov/pubmed/14608007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2003.054973 |
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