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State-dependent Block of Wild-type and Inactivation-deficient Na(+) Channels by Flecainide

The antiarrhythmic agent flecainide appears beneficial for painful congenital myotonia and LQT-3/ΔKPQ syndrome. Both diseases manifest small but persistent late Na(+) currents in skeletal or cardiac myocytes. Flecainide may therefore block late Na(+) currents for its efficacy. To investigate this po...

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Autores principales: Wang, Ging Kuo, Russell, Corinna, Wang, Sho-Ya
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2003
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234482/
https://ncbi.nlm.nih.gov/pubmed/12913091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308857
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