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Identifying Barbiturate Binding Sites in a Nicotinic Acetylcholine Receptor with [(3)H]Allyl m-Trifluoromethyldiazirine Mephobarbital, a Photoreactive Barbiturate
At concentrations that produce anesthesia, many barbituric acid derivatives act as positive allosteric modulators of inhibitory GABA(A) receptors (GABA(A)Rs) and inhibitors of excitatory nicotinic acetylcholine receptors (nAChRs). Recent research on [(3)H]R-mTFD-MPAB ([(3)H]R-5-allyl-1-methyl-5-(m-t...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3990015/ https://ncbi.nlm.nih.gov/pubmed/24563544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.090985 |
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