Sustained and Selective Suppression of Intestinal Cholesterol Synthesis by Ro 48-8071, an Inhibitor of 2,3-Oxidosqualene:Lanosterol Cyclase, in the BALB/c Mouse

The small intestine plays a fundamentally important role in regulating whole body cholesterol balance and plasma lipoprotein composition. This is articulated through the interplay of a constellation of genes that ultimately determines the net amount of chylomicron cholesterol delivered to the liver....

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Hlavní autoři: Chuang, Jen-Chieh, Valasek, Mark A., Lopez, Adam M., Posey, Kenneth S., Repa, Joyce J., Turley, Stephen D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989900/
https://ncbi.nlm.nih.gov/pubmed/24486573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.01.031
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