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Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor
Fibrogenesis involves a pathological accumulation of activated fibroblasts and extensive matrix remodeling. Profibrotic cytokines, such as TGF-β, stimulate fibroblasts to overexpress fibrotic matrix proteins and induce further expression of profibrotic cytokines, resulting in progressive fibrosis. C...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989723/ https://ncbi.nlm.nih.gov/pubmed/24508728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00243.2013 |
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