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Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF

Active canonical Wnt signaling results in recruitment of β-catenin to DNA by TCF/LEF family members, leading to transcriptional activation of TCF target genes. However, additional transcription factors have been suggested to recruit β-catenin and tether it to DNA. Here, we describe the genome-wide p...

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Bibliographic Details
Main Authors: Schuijers, Jurian, Mokry, Michal, Hatzis, Pantelis, Cuppen, Edwin, Clevers, Hans
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989608/
https://ncbi.nlm.nih.gov/pubmed/24413017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201385358
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