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IL-27, targeting antigen presenting cells, promotes Th17 differentiation and colitis in mice
Th17 cells have been implicated in autoimmunity and inflammatory bowel disease (IBD). Antigen presenting cell (APC) derived cytokines such as IL-1β and IL-6 are key mediators supporting Th17 differentiation, yet how these factors are induced in vivo remains unclear. Here we show that IL-27 acting on...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3989480/ https://ncbi.nlm.nih.gov/pubmed/24129161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.82 |
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