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IL-10 produced by antigen presenting cells inhibits bacterial-responsive TH1/TH17 cells and suppresses colitis in mice
BACKGROUND & AIMS: IL-10 deficient mice develop TH1/TH17-mediated colitis and IL-10-producing regulatory T cells suppress colitis, implicating IL-10 in maintaining mucosal homeostasis. We transferred germ-free (GF) or specific pathogen free (SPF) CD4(+) cells from wild-type (wt) or IL-10(−/−) (k...
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| Publié dans: | Gastroenterology |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4651012/ https://ncbi.nlm.nih.gov/pubmed/21679711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.04.053 |
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