A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells

PURPOSE: Apoptosis, or programmed cell death, can be leveraged as a surrogate measure of response to therapeutic interventions in medicine. Cysteine aspartic acid-specific proteases, or caspases, are essential determinants of apoptosis signaling cascades and represent promising targets for molecular...

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Main Authors: Hight, Matthew R., Cheung, Yiu-Yin, Nickels, Michael L., Dawson, Eric S., Zhao, Ping, Saleh, Samir, Buck, Jason R., Tang, Dewei, Washington, M. Kay, Coffey, Robert J., Manning, H. Charles
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3989451/
https://ncbi.nlm.nih.gov/pubmed/24573549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2444
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