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Positron Emission Tomography Imaging of Drug-Induced Tumor Apoptosis with a Caspase-Triggered Nano-aggregation Probe()

An (18)F-labeled caspase-3 sensitive nano-aggregation PET tracer ([(18)F]CSNAT) was prepared and evaluated for imaging caspase-3 activity in doxorubicin-treated tumor xenografts. This enzyme-activatable PET tracer is designed to function in a novel mechanism – enhanced retention of the (18)F activit...

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Detalhes bibliográficos
Main Authors: Shen, Bin, Jeon, Jongho, Palner, Mikael, Ye, Deju, Shuhendler, Adam, Chin, Frederick T., Rao, Jianghong
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4077287/
https://ncbi.nlm.nih.gov/pubmed/23881906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201303422
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