Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B.

The serine protease granzyme B, which is secreted by cytotoxic cells, is one of the major effectors of apoptosis in susceptible targets. To examine the apoptotic mechanism of granzyme B, we have analyzed its effect on purified proteins that are thought to be components of death pathways inherent to...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Quan, L T, Tewari, M, O'Rourke, K, Dixit, V, Snipas, S J, Poirier, G G, Ray, C, Pickup, D J, Salvesen, G S
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1996
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8700869/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.5.1972
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