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S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3
S1PR1 signaling has been shown to restrain the number and function of Tregs in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988983/ https://ncbi.nlm.nih.gov/pubmed/24630990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.016 |
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