The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31

Amplification of the EMSY gene in sporadic breast and ovarian cancers is a poor prognostic indicator. Although EMSY has been linked to transcriptional silencing, its mechanism of action is unknown. Here, we report that EMSY acts as an oncogene, causing the transformation of cells in vitro and potent...

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Bibliographische Detailangaben
Hauptverfasser: Viré, Emmanuelle, Curtis, Christina, Davalos, Veronica, Git, Anna, Robson, Samuel, Villanueva, Alberto, Vidal, August, Barbieri, Isaia, Aparicio, Samuel, Esteller, Manel, Caldas, Carlos, Kouzarides, Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988886/
https://ncbi.nlm.nih.gov/pubmed/24582497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.01.029
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