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Identification of age-specific Nrf2 binding to a novel ARE locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver?
NFE2-related factor 2 (Nrf2) transcriptionally governs the cellular response to harmful electrophiles, xenobiotics, and reactive oxygen species. Its nuclear levels decline with age (Suh et al., 2004), which in part explains the age-related loss of phase II detoxification. However, little work has ye...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988790/ https://ncbi.nlm.nih.gov/pubmed/22212472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00788.x |
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