Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I

The role of mitochondrial GSH (mGSH) in the enhanced age-related susceptibility to xenobiotic toxicity is not well defined. We determined mGSH status and indices of mitochondrial bioenergetics in hepatocytes from young and old F344 rats treated with 300 μM menadione, a concentration that causes 50%...

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Udgivet i:Redox Biol
Main Authors: Thomas, Nicholas O., Shay, Kate P., Hagen, Tory M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406584/
https://ncbi.nlm.nih.gov/pubmed/30851669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2019.101155
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