Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma

Renal oncocytomas are benign tumors characterized by a marked accumulation of mitochondria. We report a combined exome, transcriptome, and metabolome analysis of these tumors. Joint analysis of the nuclear and mitochondrial (mtDNA) genomes reveals loss-of-function mtDNA mutations occurring at high v...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Gopal, Raj K., Calvo, Sarah E., Shih, Angela R., Chaves, Frances L., McGuone, Declan, Mick, Eran, Pierce, Kerry A., Li, Yang, Garofalo, Andrea, Van Allen, Eliezer M., Clish, Clary B., Oliva, Esther, Mootha, Vamsi K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142220/
https://ncbi.nlm.nih.gov/pubmed/29915083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711888115
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