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Glutathione maintenance mitigates age-related susceptibility to redox cycling agents

Isolated hepatocytes from young (4–6 mo) and old (24–26 mo) F344 rats were exposed to increasing concentrations of menadione, a vitamin K derivative and redox cycling agent, to determine whether the age-related decline in Nrf2-mediated detoxification defenses resulted in heightened susceptibility to...

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Bibliografski detalji
Izdano u:Redox Biol
Glavni autori: Thomas, Nicholas O., Shay, Kate P., Kelley, Amanda R., Butler, Judy A., Hagen, Tory M.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040638/
https://ncbi.nlm.nih.gov/pubmed/27687220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.09.010
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