miR-34 cooperates with p53 in suppression of prostate cancer by joint regulation of stem cell compartment

MicroRNAs of miR-34 family have been originally identified as direct transactivation target of p53 and are putative tumor suppressors. Surprisingly, mice lacking all mir-34 genes show no increase in cancer formation by 18 months of age, hence placing in doubt physiological relevance of previous stud...

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Hlavní autoři: Cheng, Chieh-Yang, Hwang, Chang-Il, Corney, David C., Flesken-Nikitin, Andrea, Long-Chang, Jiang, Öner, Gülfem Meryem, Munroe, Robert J., Schimenti, John C., Hermeking, Heiko, Nikitin, Alexander Yu.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988786/
https://ncbi.nlm.nih.gov/pubmed/24630988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.023
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