Frequent downregulation of miR-34 family in human ovarian cancers

PURPOSE: The miR-34 family is directly transactivated by tumor suppressor p53 which is frequently mutated in human epithelial ovarian cancer (EOC). We hypothesized that miR-34 expression would be decreased in EOC and that reconstituted miR-34 expression might reduce cell proliferation and invasion o...

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Bibliografiske detaljer
Main Authors: Corney, David C., Hwang, Chang-il, Matoso, Andres, Vogt, Markus, Flesken-Nikitin, Andrea, Godwin, Andrew K., Kamat, Aparna A., Sood, Anil K., Ellenson, Lora H., Hermeking, Heiko, Nikitin, Alexander Yu.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2822884/
https://ncbi.nlm.nih.gov/pubmed/20145172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-2642
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