Characterization of a p53/miR-34a/CSF1R/STAT3 Feedback Loop in Colorectal Cancer

BACKGROUND & AIMS: The miR-34a gene is a direct target of p53 and is commonly silenced in colorectal cancer (CRC). Here we identified the receptor tyrosine kinase CSF1R as a direct miR-34a target and characterized CSF1R as an effector of p53/miR-34a-mediated CRC suppression. METHODS: Analyses of...

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Publicado en:Cell Mol Gastroenterol Hepatol
Autores principales: Shi, Xiaolong, Kaller, Markus, Rokavec, Matjaz, Kirchner, Thomas, Horst, David, Hermeking, Heiko
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423584/
https://ncbi.nlm.nih.gov/pubmed/32304779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.04.002
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