IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

Members of the miR-34 family are induced by the tumor suppressor p53 and are known to inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the early phases of metastasis. Here, we determined that exposure of human colorectal cancer (CRC) cells to the cytokine IL-6 act...

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Main Authors: Rokavec, Matjaz, Öner, Meryem Gülfem, Li, Huihui, Jackstadt, Rene, Jiang, Longchang, Lodygin, Dmitri, Kaller, Markus, Horst, David, Ziegler, Paul K., Schwitalla, Sarah, Slotta-Huspenina, Julia, Bader, Franz G., Greten, Florian R., Hermeking, Heiko
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973098/
https://ncbi.nlm.nih.gov/pubmed/24642471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73531
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