miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure

microRNAs (miRNAs) are crucial for cellular development and homeostasis. In order to better understand regulation of miRNA biosynthesis, we studied cleavage of primary miRNAs by Drosha. While Drosha knockdown triggers an expected decrease of many mature miRNAs in human embryonic stem cells (hESC), a...

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Hlavní autoři: Sperber, Henrik, Beem, Alan, Shannon, Sandra, Jones, Ross, Banik, Pratyusha, Chen, Yu, Ku, Sherman, Varani, Gabriele, Yao, Shuyuan, Ruohola-Baker, Hannele
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988564/
https://ncbi.nlm.nih.gov/pubmed/24677349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.043943.113
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