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miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure
microRNAs (miRNAs) are crucial for cellular development and homeostasis. In order to better understand regulation of miRNA biosynthesis, we studied cleavage of primary miRNAs by Drosha. While Drosha knockdown triggers an expected decrease of many mature miRNAs in human embryonic stem cells (hESC), a...
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| Päätekijät: | , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Cold Spring Harbor Laboratory Press
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3988564/ https://ncbi.nlm.nih.gov/pubmed/24677349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.043943.113 |
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