miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure

microRNAs (miRNAs) are crucial for cellular development and homeostasis. In order to better understand regulation of miRNA biosynthesis, we studied cleavage of primary miRNAs by Drosha. While Drosha knockdown triggers an expected decrease of many mature miRNAs in human embryonic stem cells (hESC), a...

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Detalhes bibliográficos
Main Authors: Sperber, Henrik, Beem, Alan, Shannon, Sandra, Jones, Ross, Banik, Pratyusha, Chen, Yu, Ku, Sherman, Varani, Gabriele, Yao, Shuyuan, Ruohola-Baker, Hannele
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988564/
https://ncbi.nlm.nih.gov/pubmed/24677349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.043943.113
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