miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure

microRNAs (miRNAs) are crucial for cellular development and homeostasis. In order to better understand regulation of miRNA biosynthesis, we studied cleavage of primary miRNAs by Drosha. While Drosha knockdown triggers an expected decrease of many mature miRNAs in human embryonic stem cells (hESC), a...

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Autors principals: Sperber, Henrik, Beem, Alan, Shannon, Sandra, Jones, Ross, Banik, Pratyusha, Chen, Yu, Ku, Sherman, Varani, Gabriele, Yao, Shuyuan, Ruohola-Baker, Hannele
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2014
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988564/
https://ncbi.nlm.nih.gov/pubmed/24677349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.043943.113
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