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miRNA sensitivity to Drosha levels correlates with pre-miRNA secondary structure

microRNAs (miRNAs) are crucial for cellular development and homeostasis. In order to better understand regulation of miRNA biosynthesis, we studied cleavage of primary miRNAs by Drosha. While Drosha knockdown triggers an expected decrease of many mature miRNAs in human embryonic stem cells (hESC), a...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Sperber, Henrik, Beem, Alan, Shannon, Sandra, Jones, Ross, Banik, Pratyusha, Chen, Yu, Ku, Sherman, Varani, Gabriele, Yao, Shuyuan, Ruohola-Baker, Hannele
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988564/
https://ncbi.nlm.nih.gov/pubmed/24677349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.043943.113
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