Fluorescent probes of the Isoxazole-Dihydropyridine Scaffold: MDR-1 binding and homology model

Isoxazole-1,4-Dihydropyridines (IDHPs) were tethered to Fluorescent moieties using double activation via a lanthanide assisted Weibreb amidation. IDHP-fluorophore conjugate 3c exhibits the highest binding to date for IDHPs at the multidrug-resistance transporter (MDR-1), and IDHP-fluorophore conjuga...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Szabon-Watola, Monika I., Ulatowski, Sarah V., George, Kathleen M., Hayes, Christina D., Steiger, Scott A., Natale, Nicholas R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987963/
https://ncbi.nlm.nih.gov/pubmed/24342237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.068
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares