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Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter

A series of dimeric isoxazolyl-1,4-dihydropyridines (IDHPs) were prepared by click chemistry and examined for their ability to bind the multi-drug resistance transporter (MDR-1), a member of the ATP-binding cassette superfamily (ABC). Eight compounds in the present study exhibited single digit micro...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Steiger, Scott A., Li, Chun, Backos, Donald S., Reigan, Philip, Natale, N.R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813499/
https://ncbi.nlm.nih.gov/pubmed/28434782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.04.008
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