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Fluorescent probes of the Isoxazole-Dihydropyridine Scaffold: MDR-1 binding and homology model
Isoxazole-1,4-Dihydropyridines (IDHPs) were tethered to Fluorescent moieties using double activation via a lanthanide assisted Weibreb amidation. IDHP-fluorophore conjugate 3c exhibits the highest binding to date for IDHPs at the multidrug-resistance transporter (MDR-1), and IDHP-fluorophore conjuga...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3987963/ https://ncbi.nlm.nih.gov/pubmed/24342237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.11.068 |
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