Isoxazole analogues bind the System x(c)(−) Transporter: Structure-activity Relationship and Pharmacophore Model

Analogues of amino methylisoxazole propionic acid (AMPA), were prepared from a common intermediate 12, including lipophilic analogues using lateral metalation and electrophilic quenching, and were evaluated at System x(c)(−). Both the 5-naphthylethyl-(16) and 5-naphthylmethoxymethyl-(17) analogues a...

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Main Authors: Patel, Sarjubhai A., Rajale, Trideep, O’Brien, Erin, Burkhart, David J., Nelson, Jared K., Twamley, Brendan, Blumenfeld, Alex, Szabon-Watola, Monika I., Gerdes, John M., Bridges, Richard J., Natale, Nicholas R.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2967674/
https://ncbi.nlm.nih.gov/pubmed/19932968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.11.001
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