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Do mutator mutations fuel tumorigenesis?
The mutator phenotype hypothesis proposes that the mutation rate of normal cells is insufficient to account for the large number of mutations found in human cancers. Consequently, human tumors exhibit an elevated mutation rate that increases the likelihood of a tumor acquiring advantageous mutations...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3987827/ https://ncbi.nlm.nih.gov/pubmed/23592419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10555-013-9426-8 |
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