Receptor Tyrosine Kinases Fall into Distinct Classes Based on Their Inferred Signaling Networks

Although many anticancer drugs that target receptor tyrosine kinases (RTKs) provide clinical benefit, their long-term use is limited by resistance that is often attributed to increased abundance or activation of another RTK that compensates for the inhibited receptor. To uncover common and unique fe...

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Bibliographic Details
Main Authors: Wagner, Joel P., Wolf-Yadlin, Alejandro, Sevecka, Mark, Grenier, Jennifer K., Root, David E., Lauffenburger, Douglas A., MacBeath, Gavin
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987808/
https://ncbi.nlm.nih.gov/pubmed/23861540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003994
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