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State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling
As an alternative to conventional, target-oriented drug discovery, we report a strategy that identifies compounds on the basis of the state that they induce in a signaling network. Immortalized human cells are grown in microtiter plates and treated with compounds from a small-molecule library. The t...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2692720/ https://ncbi.nlm.nih.gov/pubmed/16990815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/NMETH931 |
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