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Integrated Mimicry of B Cell Antibody Mutagenesis Using Yeast Homologous Recombination
Antibody affinity maturation proceeds in vivo via a combination of point mutations, insertions, deletions, and combinatorial shuffling of light chains or portions of the heavy chain, thereby reducing the probability of trapping in local affinity optima in sequence space. In vivo homologous recombina...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3986863/ https://ncbi.nlm.nih.gov/pubmed/20645027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12033-010-9312-3 |
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