Targeted mutagenesis by homologous recombination in D. melanogaster

We used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, including the homolog of the p53 tumor suppressor. Transgenic expression of the FLP site-specific recombinase and the I-SceI endonuclease generates extrachromosomal linear DNA molecules in vivo. These...

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Bibliografiske detaljer
Main Authors: Rong, Yikang S., Titen, Simon W., Xie, Heng B., Golic, Mary M., Bastiani, Michael, Bandyopadhyay, Pradip, Olivera, Baldomero M., Brodsky, Michael, Rubin, Gerald M., Golic, Kent G.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2002
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC186348/
https://ncbi.nlm.nih.gov/pubmed/12080094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.986602
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