Drosophila melanogaster MNK/Chk2 and p53 Regulate Multiple DNA Repair and Apoptotic Pathways following DNA Damage

We have used genetic and microarray analysis to determine how ionizing radiation (IR) induces p53-dependent transcription and apoptosis in Drosophila melanogaster. IR induces MNK/Chk2-dependent phosphorylation of p53 without changing p53 protein levels, indicating that p53 activity can be regulated...

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Detalhes bibliográficos
Main Authors: Brodsky, Michael H., Weinert, Brian T., Tsang, Garson, Rong, Yikang S., McGinnis, Nadine M., Golic, Kent G., Rio, Donald C., Rubin, Gerald M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC321428/
https://ncbi.nlm.nih.gov/pubmed/14729967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.3.1219-1231.2004
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