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MHC class I-presented peptides and the DRiP hypothesis

MHC class I molecules present peptides derived from intracellular proteins, enabling immune surveillance by CD8+ T cells and the elimination of virally infected and cancerous cells. It has been argued that the dominant source of MHC class I-presented peptides is through proteasomal degradation of ne...

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Bibliographic Details
Main Authors: Rock, Kenneth L., Farfán-Arribas, Diego J., Colbert, Jeff D., Goldberg, Alfred L.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986829/
https://ncbi.nlm.nih.gov/pubmed/24566257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2014.01.002
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