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Substrate-induced protein stabilization reveals a predominant contribution from mature protein to peptides presented on MHC class I
The origin of the MHC class I-presented peptides are thought to be primarily from newly synthesized but defective proteins, termed DRiPs. Most of the data supporting this concept come from studies where inhibitors of protein synthesis were found to rapidly block antigen presentation even when cells...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3845381/ https://ncbi.nlm.nih.gov/pubmed/24174619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300078 |
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