Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

Mice genetically engineered to be humanized for their Ig genes allow for human antibody responses within a mouse background (HumAb mice), providing a valuable platform for the generation of fully human therapeutic antibodies. Unfortunately, existing HumAb mice do not have fully functional immune sys...

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Autori principali: Murphy, Andrew J., Macdonald, Lynn E., Stevens, Sean, Karow, Margaret, Dore, Anthony T., Pobursky, Kevin, Huang, Tammy T., Poueymirou, William T., Esau, Lakeisha, Meola, Melissa, Mikulka, Warren, Krueger, Pamela, Fairhurst, Jeanette, Valenzuela, David M., Papadopoulos, Nicholas, Yancopoulos, George D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986188/
https://ncbi.nlm.nih.gov/pubmed/24706856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324022111
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