Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5

We identified a glycoprotein hormone β-subunit (OGH, also called GPB5) that, as a heterodimer with the α-subunit GPA2, serves as a second ligand for the thyroid-stimulating hormone receptor. Mice in which the OGH gene is deleted (OGH(-/-)) are indistinguishable from WT littermates in body weight, re...

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Autori principali: Macdonald, Lynn E., Wortley, Katherine E., Gowen, Lori C., Anderson, Keith D., Murray, Jane D., Poueymirou, William T., Simmons, Mary V., Barber, Dianna, Valenzuela, David M., Economides, Aris N., Wiegand, Stanley J., Yancopoulos, George D., Sleeman, Mark W., Murphy, Andrew J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC548327/
https://ncbi.nlm.nih.gov/pubmed/15699348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409849102
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