Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes

Genetic humanization, which involves replacing mouse genes with their human counterparts, can create powerful animal models for the study of human genes and diseases. One important example of genetic humanization involves mice humanized for their Ig genes, allowing for human antibody responses withi...

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Main Authors: Macdonald, Lynn E., Karow, Margaret, Stevens, Sean, Auerbach, Wojtek, Poueymirou, William T., Yasenchak, Jason, Frendewey, David, Valenzuela, David M., Giallourakis, Cosmas C., Alt, Frederick W., Yancopoulos, George D., Murphy, Andrew J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2014
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986150/
https://ncbi.nlm.nih.gov/pubmed/24706858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323896111
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