Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

Ig and T-cell receptor (TCR) variable-region gene exons are assembled from component variable (V), diversity (D) and joining (J) gene segments during early B and T cell development. The RAG1/2 endonuclease initiates V(D)J recombination by introducing DNA double-strand breaks at borders of the germ-l...

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Detalhes bibliográficos
Main Authors: Giallourakis, Cosmas C., Franklin, Andrew, Guo, Chunguang, Cheng, Hwei-Ling, Yoon, Hye Suk, Gallagher, Michael, Perlot, Thomas, Andzelm, Milena, Murphy, Andrew J., Macdonald, Lynn E., Yancopoulos, George D., Alt, Frederick W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3009784/
https://ncbi.nlm.nih.gov/pubmed/21123744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015954107
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