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Triazole derivatives with improved in vitro antifungal activity over azole drugs

A series of triazole antifungal agents with piperidine side chains was designed and synthesized. The results of antifungal tests against eight human pathogenic fungi in vitro showed that all the compounds exhibited moderate-to-excellent activities. Molecular docking between 8d and the active site of...

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Autors principals: Yu, Shichong, Chai, Xiaoyun, Wang, Yanwei, Cao, Yongbing, Zhang, Jun, Wu, Qiuye, Zhang, Dazhi, Jiang, Yuanying, Yan, Tianhua, Sun, Qingyan
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3986111/
https://ncbi.nlm.nih.gov/pubmed/24748772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S58680
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