Enhancing the Specificity of Recombinase-Mediated Genome Engineering through Dimer Interface Redesign

[Image: see text] Despite recent advances in genome engineering made possible by the emergence of site-specific endonucleases, there remains a need for tools capable of specifically delivering genetic payloads into the human genome. Hybrid recombinases based on activated catalytic domains derived fr...

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Detaylı Bibliyografya
Asıl Yazarlar: Gaj, Thomas, Sirk, Shannon J., Tingle, Ryan D., Mercer, Andrew C., Wallen, Mark C., Barbas, Carlos F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985937/
https://ncbi.nlm.nih.gov/pubmed/24611715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja4130059
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